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Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

《医学前沿（英文）》 2022年 第16卷 第5期   页码 773-783 doi: 10.1007/s11684-021-0902-1

摘要： The total number of cancer patients who are eligible for and will benefit from immune checkpoint inhibitors (ICIs) in China has not been quantified. This cross-sectional study was conducted to estimate the number of Chinese cancer patients with eligibility and response to ICIs based on the 2015 Chinese cancer statistics and the immune checkpoint inhibitor clinical practice guideline of the Chinese Society of Clinical Oncology. A total of 11 ICIs were recommended for 17 cancer types. The estimated number of eligible patients annually was 1 290 156 (55.18%), which included 888 738 males (60.05%) and 400 468 females (46.67%). The estimated number of responders annually was 448 972 (19.20%), which included 309 023 males (20.88%) and 139 764 females (16.29%). Gastric cancer (n=291 000, 12.45%), non-small-cell lung cancer (n=289 629, 12.39%), and hepatocellular carcinoma (n=277 100, 11.85%) were the top three cancer types with the highest number of eligible patients. Non-small-cell lung cancer (n=180 022, 7.70%), hepatocellular carcinoma (n=75 648, 3.24%), and small-cell lung cancer (n=64 362, 2.75%) were the top three cancer types with the highest number of responders. In conclusion, ICIs provide considerable benefit in Chinese cancer patients under optimal estimation.

关键词： benefit     China     eligibility     immune checkpoint inhibitor     public health    

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Collaborative control of fine particles and ozone required in China for health benefit

《环境科学与工程前沿（英文）》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1692-2

摘要：

● Increased DAAO offsets 3/4 of the decrease of DAAP in 2013–2020.

关键词： Excess deaths     Long-term exposure     Fine particle     Ozone    

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An assessment of the potential health benefits of realizing the goals for PM

Guoxia MA,Jinnan WANG,Fang YU,Yanshen ZHANG,Dong CAO

《环境科学与工程前沿（英文）》 2016年 第10卷 第2期   页码 288-298 doi: 10.1007/s11783-014-0738-x

摘要： As a response to the severe air quality problems in China, the Chinese Ministry of Environmental Protection in 2012 issued an updated (GB3095-2012), which set a stricter grade II PM standard. A successful implementation of this standard will have an impact on human health through reduction of exposure to air pollution in the population. Using the methods of adjusted human capital and value of statistical life, the authors in this article estimate the economic impact of a successful implementation of the updated on human health in China. The key results are: 1) The human health benefits from reaching the updated standard for PM would equal CNY 51.1 billion using adjusted human capital, accounting for 18.5% of total human health costs in China, and CNY 83.5 billion using the value of a statistical life; 2) the benefit of reaching the updated standard for PM is highest in the east coastal areas and gradually declines for more Western provinces; and 3) the marginal benefit of public health increases as the environmental quality standard PM improves. If the annual concentration of PM were to be reduced from the target number in the original grade II standard to that in the updated standard, the mortality rate of long-term exposure would be reduced by 6.5% due to reduced chronic exposure. In addition, if the annual concentration were to be reduced further from updated grade II to grade I standard, the mortality rate for long-term exposure would be lowered by 32.8%.

关键词： air quality     health benefit     Ambient Air Quality Standard     PM10     China    

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Cost-benefit analysis of China’s national air pollution control plan

Jing ZHANG, Hongqiang JIANG, Wei ZHANG, Guoxia MA, Yanchao WANG, Yaling LU, Xi HU, Jia ZHOU, Fei PENG, Jun BI, Jinnan WANG

《工程管理前沿（英文）》 2019年 第6卷 第4期   页码 524-537 doi: 10.1007/s42524-019-0074-8

摘要： China’s rapid economic growth has caused severe air pollution and public health problems. Therefore, the Chinese government launched the National Air Pollution Control Plan (hereinafter referred to as the “Air Plan”) in 2013–2017 to improve air quality and safeguard public health. In this study, an analytical framework for a cost-benefit analysis applicable to China was constructed, and the costs and benefits of the implementation of the “Air Plan” in 30 cities and provinces in China from 2013 to 2017 were evaluated. Results show that the total cost of implementation of the “Air Plan” is 1.6511 trillion RMB. The benefits of air quality improvement were determined to be 2.4691 trillion RMB through the willingness-to-pay method to calculate the economic loss of premature deaths. The net benefit related to the implementation of the “Air Plan” was 818 billion RMB. The public health benefit of air quality improvement was 1.5 times the cost of the nationwide implementation of the “Air Plan”. At the provincial level, net benefits that reach 279.3 billion RMB were the highest in Guangdong, whereas the benefit-cost ratio, where the benefit was 5.5 times the cost, was the highest in Fujian. Estimations in this study can serve as a reference for China in formulating similar environmental policies and implementing the “3-year Plan to Defend the Blue Sky”. In addition, these estimations have practical significance for advancing the long-term effective mechanisms of the cost-benefit analysis of China’s environmental policies.

关键词： Air Plan     cost-benefit analysis     health benefits     environmental policy    

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Development of an integrated policy making tool for assessing air quality and human health benefits of

Xuezhen QIU,Yun ZHU,Carey JANG,Che-Jen LIN,Shuxiao WANG,Joshua FU,Junping XIE,Jiandong WANG,Dian DING,Shicheng LONG

《环境科学与工程前沿（英文）》 2015年 第9卷 第6期   页码 1056-1065 doi: 10.1007/s11783-015-0796-8

摘要： Efficient air quality management is critical to protect public health from the adverse impacts of air pollution. To evaluate the effectiveness of air pollution control strategies, the US Environmental Protection Agency (US EPA) has developed the Software for Model Attainment Test-Community Edition (SMAT-CE) to assess the air quality attainment of emission reductions, and the Environmental Benefits Mapping and Analysis Program-Community Edition (BenMAP-CE) to evaluate the health and economic benefits of air quality improvement respectively. Since scientific decision-making requires timely and coherent information, developing the linkage between SMAT-CE and BenMAP-CE into an integrated assessment platform is desirable. To address this need, a new module linking SMAT-CE to BenMAP-CE has been developed and tested. The new module streamlines the assessment of air quality and human health benefits for a proposed air pollution control strategy. It also implements an optimized data gridding algorithm which significantly enhances the computational efficiency without compromising accuracy. The performance of the integrated software package is demonstrated through a case study that evaluates the air quality and associated economic benefits of a national-level control strategy of PM . The results of the case study show that the proposed emission reduction reduces the number of nonattainment sites from 379 to 25 based on the US National Ambient Air Quality Standards, leading to more than US$334 billion of economic benefits annually from improved public health. The integration of the science-based software tools in this study enhances the efficiency of developing effective and optimized emission control strategies for policy makers.

关键词： air quality assessment     human health benefit     economic benefit     air quality attainment assessment     air pollution control strategy     decision support system    

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泰州大桥施工营地太阳能利用综合效益分析

丁志群,徐俊,李明

《中国工程科学》 2010年 第12卷 第4期   页码 100-103

摘要：

以泰州大桥北塔，北锚施工营地为对象，从粉尘、SO2排放以及能源消耗等方面，分析了太阳能利用对比于普通燃煤锅炉对环境的影响，发现太阳能利用能明显地改善营地的环境。

关键词： 泰州大桥施工营地     太阳能     综合效益(环境效益、经济效益)    

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Reactive power deployment and cost benefit analysis in DNO operated distribution electricity markets

Atma Ram GUPTA,Ashwani KUMAR

《能源前沿（英文）》 2019年 第13卷 第1期   页码 86-98 doi: 10.1007/s11708-017-0456-8

摘要： The aim of this paper is to analyze unbalanced radial distribution systems (UBRDS) with the distribution static compensator (D-STATCOM). The main objectives of this paper are D-STATCOM allocation in UBRDS with an objective of providing reactive power support to enhance voltage profile and reduce line losses of the distribution network, determination of optimal D-STATCOM rating subjected to minimization of total cost, and impact of D-STATCOM placement on improving power factor and savings in cost of energy loss. The analysis is conducted on a large industrial load model with light, medium and high loading scenarios. Further, the impact of load growth is also considered for better planning of the power distribution system. The results are obtained on standard 25-bus UBRDS to check the feasibility of the proposed methodology.

关键词： unbalanced distribution system     D-STATCOM     voltage sensitivity index     load models     load growth     distribution network operator (DNO)    

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Primary health care for all by 2020: The systematic reform of the medical and health system in China

《医学前沿（英文）》 2010年 第4卷 第1期   页码 3-7 doi: 10.1007/s11684-010-0024-7

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Determination of 27 pharmaceuticals and personal care products (PPCPs) in water: The benefit of isotope

Xueqi Fan, Jie Gao, Wenchao Li, Jun Huang, Gang Yu

《环境科学与工程前沿（英文）》 2020年 第14卷 第1期 doi: 10.1007/s11783-019-1187-3

摘要： • Isotope dilution method was developed for the determination of 27 PPCPs in water. • The established method was successfully applied to different types of water samples. • The correction effect of corresponding 27 ILSs over 70 d was investigated. • Benefit of isotopic dilution method was illustrated for three examples. Pharmaceuticals and personal care products (PPCPs) are a unique group of emerging and non-persistent contaminants. In this study, 27 PPCPs in various water samples were extracted by solid phase extraction (SPE), and determined by isotope dilution method using liquid chromatography coupled to tandem triple quadruple mass spectrometer (LC-MS/MS). A total of 27 isotopically labeled standards (ILSs) were applied to correct the concentration of PPCPs in spiked ultrapure water, drinking water, river, effluent and influent sewage. The corrected recoveries were 73%–122% with the relative standard deviation (RSD)<16%, except for acetaminophen. The matrix effect for all kinds of water samples was<22% and the method quantitation limits (MQLs) were 0.45–8.6 ng/L. The developed method was successfully applied on environmental water samples. The SPE extracts of spiked ultrapure water, drinking water, river and wastewater effluent were stored for 70 days, and the ILSs-corrected recoveries of 27 PPCPs were obtained to evaluate the correction ability of ILSs in the presence of variety interferences. The recoveries of 27 PPCPs over 70 days were within the scope of 72%–140% with the recovery variation<37% in all cases. The isotope dilution method seems to be of benefit when the extract has to be stored for long time before the instrument analysis.

关键词： Pharmaceuticals and personal care products (PPCPs)     Isotopically labeled standard (ILSs)     Water     Solid-phase extraction (SPE)     LC-MS/MS    

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The next step of community health construction: Training general practitioners and implementing health

Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,

《医学前沿（英文）》 2010年 第4卷 第2期   页码 134-138 doi: 10.1007/s11684-010-0041-6

摘要： This article discusses the concept of health management and stresses that community health management should be the starting point of community health service, necessitating a paradigm shift from observing the treatment-oriented medical model to observing the prevention-and-health management-based medical model. Community health construction has entered a new phase, one which highlights the need to train general practitioners in practice-based life cycle health management. In addition, general practitioners should assume the mission of implementing community health management.

关键词： community health     general practitioners     health management    

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高速公路项目社会经济效益的产生机制及其评价研究

王宇宁,运迎霞,范志清

《中国工程科学》 2012年 第14卷 第10期   页码 97-102

摘要：

基于系统工程的思想，通过分析高速公路社会经济效益产生的机制，建立了区域经济—公路交通发展系统动力学模型，以天津市津蓟高速公路为例，通过系统仿真误差检验，证实了该系统动力学模型的仿真效果较好、性能稳定。通过已建—未建高速公路系统仿真结果的有无对比，计算并预测出了津蓟高速公路2003—2013年各年的社会经济效益，从而实现了高速公路项目社会经济效益评价的定量化目标，为今后类似项目的开展提供了理论指导。

关键词： 高速公路项目     社会经济效益     评价     系统动力学    

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Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake

《环境科学与工程前沿（英文）》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1475-6

摘要：

• The concentrations of 13 heavy metals in Taihu Lake were analyzed.

关键词： Heavy metals     Human health ambient water quality criteria     Taihu Lake     Health risk assessment     Contribution rate    

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Percolation-based health management of complex traffic systems

《工程管理前沿（英文）》 2021年 第8卷 第4期   页码 557-571 doi: 10.1007/s42524-021-0174-0

摘要： System health management, which aims to ensure the safe and efficient operation of systems by reducing uncertain risks and cascading failures during their lifetime, is proposed for complex transportation systems and other critical infrastructures, especially under the background of the New Infrastructure Projects launched in China. Previous studies proposed numerous approaches to evaluate or improve traffic reliability or efficiency. Nevertheless, most existing studies neglected the core failure mechanism (i.e., spatio–temporal propagation of traffic congestion). In this article, we review existing studies on traffic reliability management and propose a health management framework covering the entire traffic congestion lifetime, from emergence, evolution to dissipation, based on the study of core failure modes with percolation theory. Aiming to be “reliable, invulnerable, resilient, potential, and active”, our proposed traffic health management framework includes modeling, evaluation, diagnosis, and improvement. Our proposed framework may shed light on traffic management for megacities and urban agglomerations around the world. This new approach may offer innovative insights for systems science and engineering in future intelligent infrastructure management.

关键词： traffic health     health management     critical infrastructure     systems science and engineering    

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Structural health monitoring with fiber optic sensors

F. ANSARI

《机械工程前沿（英文）》 2009年 第4卷 第2期   页码 103-110 doi: 10.1007/s11465-009-0032-y

摘要： Optical fiber sensors have been successfully implemented in aeronautics, mechanical systems, and medical applications. Civil structures pose further challenges in monitoring mainly due to their large dimensions, diversity and heterogeneity of materials involved, and hostile construction environment. This article provides a summary of basic principles pertaining to practical health monitoring of civil engineering structures with optical fiber sensors. The issues discussed include basic sensor principles, strain transfer mechanism, sensor packaging, sensor placement in construction environment, and reliability and survivability of the sensors.

关键词： Bridges     structural health monitoring     smart skins     cracks     strains     displacements     fiber optic sensors     FBG     structures    

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Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1376-0

摘要：

•Annual mean PM2.5 in Shijiazhuang were 87, 95, and 82 µg/m3 in 2015–2017.

关键词： PM2.5     Health effects     Integrated exposure-response model     Shijiazhuang    

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标题 作者 时间 类型 操作

Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

期刊论文

Collaborative control of fine particles and ozone required in China for health benefit

期刊论文

An assessment of the potential health benefits of realizing the goals for PM

Guoxia MA,Jinnan WANG,Fang YU,Yanshen ZHANG,Dong CAO

期刊论文

Cost-benefit analysis of China’s national air pollution control plan

Jing ZHANG, Hongqiang JIANG, Wei ZHANG, Guoxia MA, Yanchao WANG, Yaling LU, Xi HU, Jia ZHOU, Fei PENG, Jun BI, Jinnan WANG

期刊论文

Development of an integrated policy making tool for assessing air quality and human health benefits of

Xuezhen QIU,Yun ZHU,Carey JANG,Che-Jen LIN,Shuxiao WANG,Joshua FU,Junping XIE,Jiandong WANG,Dian DING,Shicheng LONG

期刊论文

泰州大桥施工营地太阳能利用综合效益分析

丁志群,徐俊,李明

期刊论文

Reactive power deployment and cost benefit analysis in DNO operated distribution electricity markets

Atma Ram GUPTA,Ashwani KUMAR

期刊论文

Primary health care for all by 2020: The systematic reform of the medical and health system in China

期刊论文

Determination of 27 pharmaceuticals and personal care products (PPCPs) in water: The benefit of isotope

Xueqi Fan, Jie Gao, Wenchao Li, Jun Huang, Gang Yu

期刊论文

The next step of community health construction: Training general practitioners and implementing health

Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,

期刊论文

高速公路项目社会经济效益的产生机制及其评价研究

王宇宁,运迎霞,范志清

期刊论文

Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake

期刊论文

Percolation-based health management of complex traffic systems

期刊论文

Structural health monitoring with fiber optic sensors

F. ANSARI

期刊论文

Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

期刊论文